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Glomerular transcriptome from subjects in the NEPTUNE cohort

ABSTRACT: Glomerular Transcriptome from subjects in the NEPTUNE cohort. A number of samples profiled in this analysis were also profiled in Series GSE68127, and Series GSE108113. RNA from the glomerular compartment of was extracted and processed for hybridization on Affymetrix microarrays. Contributor: NEPTUNE Consortium. This dataset is part of the TransQST collection.

ORGANISM(S): Homo sapiens

SUBMITTER: Sean Eddy

PROVIDER: E-GEOD-104066 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Hydroxypropyl-β-cyclodextrin protects from kidney disease in experimental Alport syndrome and focal segmental glomerulosclerosis.

Mitrofanova Alla A Molina Judith J Varona Santos Javier J Guzman Johanna J Morales Ximena A XA Ducasa G Michelle GM Bryn Jonathan J Sloan Alexis A Volosenco Ion I Kim Jin-Ju JJ Ge Mengyuan M Mallela Shamroop K SK Kretzler Matthias M Eddy Sean S Martini Sebastian S Wahl Patricia P Pastori Santiago S Mendez Armando J AJ Burke George W GW Merscher Sandra S Fornoni Alessia A

Kidney international 20181006 6

Studies suggest that altered renal lipid metabolism plays a role in the pathogenesis of diabetic kidney disease and that genetic or pharmacological induction of cholesterol efflux protects from the development of diabetic kidney disease and focal segmental glomerulosclerosis (FSGS). Here we tested whether altered lipid metabolism contributes to renal failure in the Col4a3 knockout mouse model for Alport Syndrome. There was an eight-fold increase in the cholesterol content in renal cortexes of mi ...[more]

PMID: 30301568

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