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V/SVZ (ventricular/subventricular zone) tissue and CP (cortical plate) tissue at E16

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Itsuki Ajioka

PROVIDER: E-GEOD-37625 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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V/SVZ (ventricular/subventricular zone) tissue and CP (cortical plate) tissue at E16

Project description:This SuperSeries is composed of the SubSeries listed below.

2014-01-01 | GSE37625 | GEO

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Project description:Cell differentiation and proliferation are mutually exclusive. Although differentiating neurons are recognized as post-mitotic non-dividing cells, some Rb- and Rb family (Rb, p107, and p130)-deficient differentiating neurons proliferate and form tumor. Here, we found that the acute inactivation of all Rb family in differentiating cortical excitatory neurons caused radial migration defect and S-phase progression but not cell division, whereas that in cortical progenitors caused the cell division of the differentiating neurons generated from Rb –/–; p107 –/–; p130 –/– (Rb-TKO) progenitors. Genome-wide DNA methylation analysis revealed that proximal promoters tended to become methylated during differentiation in vivo. DNA demethylation by DNA methyltransferase inhibitor allowed the acutely inactivated Rb-TKO differentiating neurons to undergo G2/M-phase progression. Our finding illustrate that cortical excitatory neurons epigenetically lose their proliferative potency after neurogenesis. 1 sample of the V/SVZ tissue and the CP tissue

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MBD-Seq of the V/SVZ and the CP at E16

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Gene expression profile of the V/SVZ and the CP at E16

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Gene expression profile of the V/SVZ and the CP at E16

Project description:Cell differentiation and proliferation are mutually exclusive. Although differentiating neurons are recognized as post-mitotic non-dividing cells, some Rb- and Rb family (Rb, p107, and p130)-deficient differentiating neurons proliferate and form tumor. Here, we found that the acute inactivation of all Rb family in differentiating cortical excitatory neurons caused radial migration defect and S-phase progression but not cell division, whereas that in cortical progenitors caused the cell division of the differentiating neurons generated from Rb â??/â??; p107 â??/â??; p130 â??/â?? (Rb-TKO) progenitors. Genome-wide DNA methylation analysis revealed that proximal promoters tended to become methylated during differentiation in vivo. DNA demethylation by DNA methyltransferase inhibitor allowed the acutely inactivated Rb-TKO differentiating neurons to undergo G2/M-phase progression. Our finding illustrate that cortical excitatory neurons epigenetically lose their proliferative potency after neurogenesis. 4 samples of the V/SVZ (ventricular/subventricular zone) tissue and 4 samples of the CP (cortical plate) tissue

2016-07-03 | E-GEOD-37576 | biostudies-arrayexpress

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Project description:Single-cell gene expression data from Ventricular-Subventricular Zone (V-SVZ) cells

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