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Gender dependent expression

ABSTRACT: Gender dependent gene expression in the kidney of 36 day old rats using the Affymetrix GeneChip rat expression set 230 array RAE230A. mixed model ANOVA using log2 transformed signal intensity of PM. Keywords: repeat Three rat strains Mhm, Us and MhmBN were examined. Three arrays were performed for each gender and strain combination. Total RNA from three rats was pooled for each array.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Li Li

PROVIDER: E-GEOD-3778 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Faster rates of post-puberty kidney deterioration in males is correlated with elevated oxidative stress in males vs females at early puberty.

Li Li L Boehn Susanne N SN Yu Xiaolei X Zhang Qingqin Q Kenzelmann Marc M Techel Dieter D Mohamed Salah A SA Jakob Petra P Kraenzlin Bettina B Hoffmann Sigrid S Gretz Norbert N

BMC genomics 20070709

<h4>Background</h4>Post-puberty deterioration of kidneys is more rapid in males than in females. To reveal the underlying molecular mechanisms for this difference, we analyzed gender-dependent gene expression in kidneys of three groups of 36 day-old rats.<h4>Results</h4>The number of genes exhibiting gender-dependent expression was highly influenced by the genetic background of the rat group examined. 373, 288 and 79 genes showed differential gene expression between males and females (p = 0.001) ...[more]

PMID: 17620128

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Gender dependent expression

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2006-12-31 | GSE3778 | GEO

Expression data from kidney of 36d old PKD/Mhm rats.

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Transcription profiling of rat kidney from male and female heterozygous PKD/Mhm and wild type animals

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Hypertensive Rat Kidney Study: Gender-Selective Responses to Salt in Dahl-Iwai & Sprague-Dawley Rats

Project description:Dahl-Iwai (DI) salt-sensitive rats were studied using microarrays to identify gender-specific differences in the kidney, both basal differences and responses to a high salt diet. In DI rat kidneys, gene expression profiles demonstrated inflammatory and fibrotic responses selectively in females. Gonadectomy of DI rats abrogated gender differences in gene expression. Gonadectomized female and gonadectomized male DI rats both responded to high salt with the same spectrum of gene expression changes as intact female DI rats. Androgens dominated the gender selective responses to salt. Several androgen-responsive genes were identified with roles potentiating the differential responses to salt including increased male expression of Angiotensin-Vasopressin Receptor and Prolactin Receptor, decreased 5-alpha reductase, and mixed increases and decreases in expression of Cyp4a- genes that can produce eicosanoid hormones. These gender differences potentiate sodium retention by males, and increase kidney function during gestation by females. Keywords: Disease-State Analysis (Salt-Sensitive Hypertension)

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Transcription profiling of rat model of hypertension kidney reveals gender-selective responses to salt in Dahl-Iwai and Sprague-Dawley strains

Project description:Dahl-Iwai (DI) salt-sensitive rats were studied using microarrays to identify gender-specific differences in the kidney, both basal differences and responses to a high salt diet. In DI rat kidneys, gene expression profiles demonstrated inflammatory and fibrotic responses selectively in females. Gonadectomy of DI rats abrogated gender differences in gene expression. Gonadectomized female and gonadectomized male DI rats both responded to high salt with the same spectrum of gene expression changes as intact female DI rats. Androgens dominated the gender selective responses to salt. Several androgen-responsive genes were identified with roles potentiating the differential responses to salt including increased male expression of Angiotensin-Vasopressin Receptor and Prolactin Receptor, decreased 5-alpha reductase, and mixed increases and decreases in expression of Cyp4a- genes that can produce eicosanoid hormones. These gender differences potentiate sodium retention by males, and increase kidney function during gestation by females. Experiment Overall Design: - 68 samples/rats/data tables are represented. Experiment Overall Design: - One microarray was used for each sample. Experiment Overall Design: - 3 rat

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Gender differences of gene expression profiles in brain cardiovascular centers of WKY rats [hypothalamus]

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Burn-CLP

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Toxicogenomic Analysis of Gender, Chemical, and Dose Effects in Livers of TCDD- or Aroclor 1254-Exposed Rats

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