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Transcription profiling of rat kidney from male and female heterozygous PKD/Mhm and wild type animals

ABSTRACT: Gender has strong impact on kidney performance. Female gender tends to be renal protective. PKD/Mhm is rat model for human polycystic kidney disease (PKD) caused by a mutation in gene Anks6. PKD progresses faster in male rats compared with females. We used microarrays to detect gender-dependent gene expression in kidney of 36d old PKD/Mhm rats. Experiment Overall Design: Gender-dependent gene expression was examined both in heterozygous PKD/Mhm rats affected with PKD and in their wild type littermates. Three microarrays were hybridized for each combination of gender and genotype.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Li Li

PROVIDER: E-GEOD-13065 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression data from kidney of 36d old PKD/Mhm rats.

Project description:Gender has strong impact on kidney performance. Female gender tends to be renal protective. PKD/Mhm is rat model for human polycystic kidney disease (PKD) caused by a mutation in gene Anks6. PKD progresses faster in male rats compared with females. We used microarrays to detect gender-dependent gene expression in kidney of 36d old PKD/Mhm rats. Keywords: gender, genotype

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