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SCL006,icSARS CoV Urbani or icSARS Bat SRBD (spike receptor binding domain from the wild type strain Urbani to allow for infection of human and non-human primate cells) infections of the 2B4 clonal derivative of Calu-3 cells - Time course

ABSTRACT: Purpose of experiment was to compare transcriptomics of 2B4 cells (clonal derivative of Calu-3 cells) infected with either icSARS CoV or the icSARS deltaORF6 mutant. Calu-3 cells were infected with either icSARS CoV or the cSARS Bat SRBD strain at MOI of 1.0. Cells samples were collected at 0, 7, 12, 24, 30, 36, 48, 54, 60 or 72h post infection. Each infected sample was done in triplicate. (Triplicates are defined as 3 different wells, plated at the same time using the same cell stock for all replicates.)There are triplicate time-matched mock for each time point from the same cell stock as rest of samples. Culture medium (the same as what the virus stock is in) was used for the mock infections. Contributor: The NIAID Systems Virology Center

ORGANISM(S): Homo sapiens

SUBMITTER: Richard Green 

PROVIDER: E-GEOD-37827 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A comprehensive collection of systems biology data characterizing the host response to viral infection.

Aevermann Brian D BD   Pickett Brett E BE   Kumar Sanjeev S   Klem Edward B EB   Agnihothram Sudhakar S   Askovich Peter S PS   Bankhead Armand A   Bolles Meagen M   Carter Victoria V   Chang Jean J   Clauss Therese R W TR   Dash Pradyot P   Diercks Alan H AH   Eisfeld Amie J AJ   Ellis Amy A   Fan Shufang S   Ferris Martin T MT   Gralinski Lisa E LE   Green Richard R RR   Gritsenko Marina A MA   Hatta Masato M   Heegel Robert A RA   Jacobs Jon M JM   Jeng Sophia S   Josset Laurence L   Kaiser Shari M SM   Kelly Sara S   Law G Lynn GL   Li Chengjun C   Li Jiangning J   Long Casey C   Luna Maria L ML   Matzke Melissa M   McDermott Jason J   Menachery Vineet V   Metz Thomas O TO   Mitchell Hugh H   Monroe Matthew E ME   Navarro Garnet G   Neumann Gabriele G   Podyminogin Rebecca L RL   Purvine Samuel O SO   Rosenberger Carrie M CM   Sanders Catherine J CJ   Schepmoes Athena A AA   Shukla Anil K AK   Sims Amy A   Sova Pavel P   Tam Vincent C VC   Tchitchek Nicolas N   Thomas Paul G PG   Tilton Susan C SC   Totura Allison A   Wang Jing J   Webb-Robertson Bobbie-Jo BJ   Wen Ji J   Weiss Jeffrey M JM   Yang Feng F   Yount Boyd B   Zhang Qibin Q   McWeeney Shannon S   Smith Richard D RD   Waters Katrina M KM   Kawaoka Yoshihiro Y   Baric Ralph R   Aderem Alan A   Katze Michael G MG   Scheuermann Richard H RH  

Scientific data 20141014

The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems level. This program generated 47 transcriptomic and proteomic datasets from 30 studies that investigate in vivo and in vitro host responses to viral infections. Human pathogens in the Orthomyxoviridae and Coronaviridae families, especially pandemic H1N1 and avian H5N1 influenza A viruses and severe ac  ...[more]

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