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Differential Chromatin Binding of the Drosophila Dosage Compensation Complex

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Tobias Straub

PROVIDER: E-GEOD-37865 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Different chromatin interfaces of the Drosophila dosage compensation complex revealed by high-shear ChIP-seq.

Straub Tobias T Zabel Angelika A Gilfillan Gregor D GD Feller Christian C Becker Peter B PB

Genome research 20121211 3

Transcriptional enhancement of X-linked genes to compensate for the sex chromosome monosomy in Drosophila males is brought about by a ribonucleoprotein assembly called Male-Specific-Lethal or Dosage Compensation Complex (MSL-DCC). This machinery is formed in male flies and specifically associates with active genes on the X chromosome. After assembly at dedicated high-affinity "entry" sites (HAS) on the X chromosome, the complex distributes to the nearby active chromatin. High-resolution, genome- ...[more]

PMID: 23233545

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