Unknown,Transcriptomics,Genomics,Proteomics

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Cdk11-Cyclin L controls the assembly of the RNA polymerase II Mediator


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Schizosaccharomyces pombe

SUBMITTER: Harm Bakel 

PROVIDER: E-GEOD-37962 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Cdk11-cyclinL controls the assembly of the RNA polymerase II mediator complex.

Drogat Julie J   Migeot Valérie V   Mommaerts Elise E   Mullier Caroline C   Dieu Marc M   van Bakel Harm H   Hermand Damien D  

Cell reports 20121101 5


The large Mediator (L-Mediator) is a general coactivator of RNA polymerase II transcription and is formed by the reversible association of the small Mediator (S-Mediator) and the kinase-module-harboring Cdk8. It is not known how the kinase module association/dissociation is regulated. We describe the fission yeast Cdk11-L-type cyclin pombe (Lcp1) complex and show that its inactivation alters the global expression profile in a manner very similar to that of mutations of the kinase module. Cdk11 i  ...[more]

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