Ontology highlight
ABSTRACT:
ORGANISM(S): Schizosaccharomyces pombe
SUBMITTER: Harm Bakel
PROVIDER: E-GEOD-37962 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Drogat Julie J Migeot Valérie V Mommaerts Elise E Mullier Caroline C Dieu Marc M van Bakel Harm H Hermand Damien D
Cell reports 20121101 5
The large Mediator (L-Mediator) is a general coactivator of RNA polymerase II transcription and is formed by the reversible association of the small Mediator (S-Mediator) and the kinase-module-harboring Cdk8. It is not known how the kinase module association/dissociation is regulated. We describe the fission yeast Cdk11-L-type cyclin pombe (Lcp1) complex and show that its inactivation alters the global expression profile in a manner very similar to that of mutations of the kinase module. Cdk11 i ...[more]