Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Hans WIDLUND
PROVIDER: E-GEOD-38007 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Haq Rizwan R Shoag Jonathan J Andreu-Perez Pedro P Yokoyama Satoru S Edelman Hannah H Rowe Glenn C GC Frederick Dennie T DT Hurley Aeron D AD Nellore Abhinav A Kung Andrew L AL Wargo Jennifer A JA Song Jun S JS Fisher David E DE Arany Zolt Z Widlund Hans R HR
Cancer cell 20130307 3
Activating mutations in BRAF are the most common genetic alterations in melanoma. Inhibition of BRAF by small molecules leads to cell-cycle arrest and apoptosis. We show here that BRAF inhibition also induces an oxidative phosphorylation gene program, mitochondrial biogenesis, and the increased expression of the mitochondrial master regulator, PGC1α. We further show that a target of BRAF, the melanocyte lineage factor MITF, directly regulates the expression of PGC1α. Melanomas with activation of ...[more]