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Dysregulated expression of genes in regulatory T cells from metastatic castration-resistant prostate cancer patients

ABSTRACT: We analyzed the global gene expression pattern of Tregs between healthy donors and prostate cancer patients. We found that genes related to cell cycle, cellular proliferation, immune responses, hematological system development and function were differentially expressed in Tregs from prostate cancer patients. Total RNA samples of Tregs, isolated from peripheral blood, were obtained from three separate healthy donors and three metastatic castration-resistant prostate cancer patients. Global gene expression pattern was examined by performing GeneChip microarray hybridization. Genes differentially expressed between the two groups of donors were sorted and categorized based on their biological functions.

ORGANISM(S): Homo sapiens

SUBMITTER: Alan Lap-Yin Pang 

PROVIDER: E-GEOD-38043 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Up-regulation of proliferative and migratory genes in regulatory T cells from patients with metastatic castration-resistant prostate cancer.

Huen Ngar-Yee NY   Pang Alan Lap-Yin AL   Tucker Jo A JA   Lee Tin-Lap TL   Vergati Matteo M   Jochems Caroline C   Intrivici Chiara C   Cereda Vittore V   Chan Wai-Yee WY   Rennert Owen M OM   Madan Ravi A RA   Gulley James L JL   Schlom Jeffrey J   Tsang Kwong Y KY  

International journal of cancer 20130212 2

A higher frequency of regulatory T cells (Tregs) has been observed in peripheral blood mononuclear cells (PBMC) of patients with different types of solid tumors and hematological malignancies as compared to healthy donors. In prostate cancer patients, Tregs in PBMC have been shown to have increased suppressive function. Tumor-induced biological changes in Tregs may enable tumor cells to escape immunosurveillance. We performed genome-wide expression analyses comparing the expression levels of mor  ...[more]

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