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Hepatic transcriptome in wild-type and LXR-deficient mice

ABSTRACT: LXR is a transcription factor. Two isoforms exist in mice (alpha and beta). They are both expressed in the liver. We examined the role of LXR by obtaining gene expression profiles from the livers of wild-type and LXR-/- mice from the same genetic background. Liver gene expression was measured from male mice (5 mice/group) of genotypes wild-type and LXR-/- on a mixed Sv129/C57Bl6J background (Repa et al. , 2000, Science, 289(5484):1524-9; Cummins et al., 2006, J Clin Invest,116(7):1902-12) fed for 7 weeks a normal diet (ND) or a Western diet (WD).

ORGANISM(S): Mus musculus

SUBMITTER: Pascal Martin

PROVIDER: E-GEOD-38083 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARα.

Ducheix Simon S Podechard Normand N Lasserre Frédéric F Polizzi Arnaud A Pommier Aurélien A Murzilli Stefania S Di Lisio Chiara C D'Amore Simona S Bertrand-Michel Justine J Montagner Alexandra A Pineau Thierry T Loiseau Nicolas N Lobaccaro Jean-Marc JM Martin Pascal G P PG Guillou Hervé H

Biochimie 20121010 3

The Liver X Receptors (LXRs) α and β and the Peroxisome Proliferator-Activated Receptor α (PPARα) are transcription factors that belong to class II nuclear receptors. They drive the expression of genes involved in hepatic lipid homeostasis and therefore are important targets for the prevention and treatment of nonalcoholic fatty liver disease (NAFLD). LXRs and PPARα are regulated by endogenous ligands, oxysterols and fatty acid derived molecules, respectively. In the liver, pharmacological activ ...[more]

PMID: 23063693

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