Hepatic transcriptome of mice with a deletion of the miR-379/miR-410 cluster
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Pascal Martin
PROVIDER: E-GEOD-47159 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation.
Labialle Stéphane S Marty Virginie V Bortolin-Cavaillé Marie-Line ML Hoareau-Osman Magali M Pradère Jean-Philippe JP Valet Philippe P Martin Pascal G P PG Cavaillé Jérôme J
The EMBO journal 20140814 19
In mammals, birth entails complex metabolic adjustments essential for neonatal survival. Using a mouse knockout model, we identify crucial biological roles for the miR-379/miR-410 cluster within the imprinted Dlk1-Dio3 region during this metabolic transition. The miR-379/miR-410 locus, also named C14MC in humans, is the largest known placental mammal-specific miRNA cluster, whose 39 miRNA genes are expressed only from the maternal allele. We found that heterozygote pups with a maternal--but not ...[more]
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