Unknown,Transcriptomics,Genomics,Proteomics

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Leptin and the Placental Response to Maternal Food Restriction during Early Pregnancy


ABSTRACT: Concentrations of leptin decline during food restriction. This study was designed to test the hypothesis that some of the effects of maternal food restriction on placental development are mediated by the loss of leptin. Mice were randomized to 3 treatment groups on day 1.5 of pregnancy: (1) ad libitum fed (control) (2) 50% food restriction (restricted) (3) 50% food restriction with leptin replacement (1µg/g body weight/day) (leptin). On day 11.5 placentas were collected, and two placentas from each mother were pooled for microarray analysis.

ORGANISM(S): Mus musculus

SUBMITTER: Laura Schulz 

PROVIDER: E-GEOD-38095 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Leptin and the placental response to maternal food restriction during early pregnancy in mice.

Schulz Laura Clamon LC   Schlitt Jessica M JM   Caesar Gerialisa G   Pennington Kathleen A KA  

Biology of reproduction 20121116 5


Several studies have demonstrated that maternal undernutrition or overnutrition during pregnancy can have negative consequences for the health of children born to these pregnancies, but the physiological mechanisms by which this occurs are not completely understood. During periods of food restriction, concentrations of leptin decline, whereas leptin is elevated in obesity, suggesting that it may play a role in the response to altered nutrition during pregnancy. This study compares placental deve  ...[more]

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