Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Deborah Nejman
PROVIDER: E-GEOD-38142 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nejman Deborah D Straussman Ravid R Steinfeld Israel I Ruvolo Michael M Roberts Douglas D Yakhini Zohar Z Cedar Howard H
Cancer research 20140122 5
De novo methylation of CpG islands is seen in many cancers, but the general rules governing this process are not known. By analyzing DNA from tumors, as well as normal tissues, and by utilizing a range of published data, we have identified a universal set of tumor targets, each with its own "coefficient" of methylation that is largely correlated with its inherent relative ability to recruit polycomb. This pattern is initially formed by a slow process of de novo methylation that occurs during agi ...[more]