Dynamic changes of DNA methylome and hydroxymethylome during neural differentiation of hES cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Young Kyu Park
PROVIDER: E-GEOD-38217 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Dynamic changes in DNA methylation and hydroxymethylation when hES cells undergo differentiation toward a neuronal lineage.
Kim Mirang M Park Young-Kyu YK Kang Tae-Wook TW Lee Sang-Hun SH Rhee Yong-Hee YH Park Jong-Lyul JL Kim Hee-Jin HJ Lee Daeyoup D Lee Doheon D Kim Seon-Young SY Kim Yong Sung YS
Human molecular genetics 20130918 3
DNA methylation and hydroxymethylation have been implicated in normal development and differentiation, but our knowledge is limited about the genome-wide distribution of 5-methylcytosine (5 mC) and 5-hydroxymethylcytosine (5 hmC) during cellular differentiation. Using an in vitro model system of gradual differentiation of human embryonic stem (hES) cells into ventral midbrain-type neural precursor cells and terminally into dopamine neurons, we observed dramatic genome-wide changes in 5 mC and 5 ...[more]
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