Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Tamara Seredenin
PROVIDER: E-GEOD-38219 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Mielcarek Michal M Landles Christian C Weiss Andreas A Bradaia Amyaouch A Seredenina Tamara T Inuabasi Linda L Osborne Georgina F GF Wadel Kristian K Touller Chrystelle C Butler Rachel R Robertson Janette J Franklin Sophie A SA Smith Donna L DL Park Larry L Marks Paul A PA Wanker Erich E EE Olson Eric N EN Luthi-Carter Ruth R van der Putten Herman H Beaumont Vahri V Bates Gillian P GP
PLoS biology 20131126 11
Histone deacetylase (HDAC) 4 is a transcriptional repressor that contains a glutamine-rich domain. We hypothesised that it may be involved in the molecular pathogenesis of Huntington's disease (HD), a protein-folding neurodegenerative disorder caused by an aggregation-prone polyglutamine expansion in the huntingtin protein. We found that HDAC4 associates with huntingtin in a polyglutamine-length-dependent manner and co-localises with cytoplasmic inclusions. We show that HDAC4 reduction delayed c ...[more]