Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Howard Chang
PROVIDER: E-GEOD-3825 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Chi Jen-Tsan JT Chang Howard Y HY Wang Nancy N NN Chang Dustin S DS Dunphy Nina N Brown Patrick O PO
Proceedings of the National Academy of Sciences of the United States of America 20030502 11
RNA interference (RNAi) is an evolutionarily conserved mechanism in plant and animal cells that directs the degradation of messenger RNAs homologous to short double-stranded RNAs termed small interfering RNA (siRNA). The ability of siRNA to direct gene silencing in mammalian cells has raised the possibility that siRNA might be used to investigate gene function in a high throughput fashion or to modulate gene expression in human diseases. The specificity of siRNA-mediated silencing, a critical co ...[more]