Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Eleftherios Papoutsakis
PROVIDER: E-GEOD-3838 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Fuhrken Peter G PG Chen Chi C Miller William M WM Papoutsakis Eleftherios T ET
Experimental hematology 20070301 3
<h4>Objectives</h4>Little is known about the transcriptional events underlying megakaryocytic (Mk) differentiation. We sought to identify genes and pathways previously unassociated with megakaryopoiesis and to evaluate the CHRF-288-11 (CHRF) megakaryoblastic cell line as a model system for investigating megakaryopoiesis.<h4>Methods</h4>Using DNA microarrays, Q-RT-PCR, and protein-level assays, we compared the dynamic gene expression pattern of phorbol ester-induced differentiation of CHRF cells ...[more]