PCR array of inflammatory cytokines and receptors in mouse lungs with NF-kappaB RelA mutant in alveolar epithelial cells during pneumococcal pneumonia
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Kazuko Yamamoto
PROVIDER: E-GEOD-38399 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Type I alveolar epithelial cells mount innate immune responses during pneumococcal pneumonia.
Yamamoto Kazuko K Ferrari Joseph D JD Cao Yuxia Y Ramirez Maria I MI Jones Matthew R MR Quinton Lee J LJ Mizgerd Joseph P JP
Journal of immunology (Baltimore, Md. : 1950) 20120727 5
Pneumonia results from bacteria in the alveoli. The alveolar epithelium consists of type II cells, which secrete surfactant and associated proteins, and type I cells, which constitute 95% of the surface area and meet anatomic and structural needs. Other than constitutively expressed surfactant proteins, it is unknown whether alveolar epithelial cells have distinct roles in innate immunity. Because innate immunity gene induction depends on NF-κB RelA (also known as p65) during pneumonia, we gener ...[more]
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