Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Jung-Hyun Park
PROVIDER: E-GEOD-49264 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Tinsley Kevin W KW Hong Changwan C Luckey Megan A MA Park Joo-Young JY Kim Grace Y GY Yoon Hee-Won HW Keller Hilary R HR Sacks Andrew J AJ Feigenbaum Lionel L Park Jung-Hyun JH
Blood 20130801 14
The zinc-finger protein Ikaros is a key player in T-cell development and a potent tumor suppressor in thymocytes. To understand the molecular basis of its function, we disabled Ikaros activity in vivo using a dominant negative Ikaros transgene (DN-IkTg). In DN-IkTg mice, T-cell development was severely suppressed, and positively selected thymocytes clonally expanded, resulting in a small thymus with a heavily skewed T-cell receptor (TCR) repertoire. Notably, DN-IkTg induced vigorous proliferatio ...[more]