DNA methylation dynamics during in vivo differentiation of blood and skin stem cells

ABSTRACT: DNA methylation is a mechanism of epigenetic regulation that is common to all vertebrates. Functional studies support its relevance for tissue homeostasis, but the global dynamics of DNA methylation during in vivo differentiation have not been worked out in detail. Here we report high-resolution DNA methylation maps of adult stem cell differentiation in mouse, focusing on 19 purified cell populations of the blood and skin lineages. Except for global demethylation in erythrocytes, observed DNA methylation changes were locus-specific and relatively modest in size. They frequently overlapped with lineage-associated transcription factors and their binding sites, suggesting that DNA methylation may protect cells from aberrant transcription factor activation. DNA methylation and gene expression

ORGANISM(S): Mus musculus

SUBMITTER: Christoph Bock 

PROVIDER: E-GEOD-38557 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress