Ontology highlight
ABSTRACT:
ORGANISM(S): Arabidopsis thaliana
SUBMITTER: Bin Yu
PROVIDER: E-GEOD-38600 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ren Guodong G Xie Meng M Dou Yongchao Y Zhang Shuxin S Zhang Chi C Yu Bin B
Proceedings of the National Academy of Sciences of the United States of America 20120716 31
MicroRNAs (miRNAs) are regulators of gene expression in plants and animals. The biogenesis of miRNAs is precisely controlled to secure normal development of organisms. Here we report that TOUGH (TGH) is a component of the DCL1-HYL1-SERRATE complex that processes primary transcripts of miRNAs [i.e., primary miRNAs (pri-miRNAs)] into miRNAs in Arabidopsis. Lack of TGH impairs multiple DCL activities in vitro and reduces the accumulation of miRNAs and siRNAs in vivo. TGH is an RNA-binding protein, ...[more]