The developmental patterning of 5-hydroxymethylcytosine during neuronal differentiation

ABSTRACT: Recent analyses of 5-hydroxymethylcytosine (5hmC) suggest that the modified base influences transcription by acting as an intermediate to demethylation. However, elevated levels of 5hmC within neural tissues suggest that the mark is stable and may directly contribute to gene regulation. Here, we characterize the in vivo genomic patterning and stability of 5hmC in three defined developmental states of the mouse main olfactory epithelium – multipotent stem cells, neuronal progenitors, and mature olfactory sensory neurons. 5hmC is globally enriched in neuronal progenitors and neurons relative to the stem population with significant enrichment on the bodies of transcriptionally active genes and intergenic enhancers. Although gene body 5hmC levels are positively correlated with cell type-specif

ORGANISM(S): Mus musculus

SUBMITTER: Bradley Colquitt 

PROVIDER: E-GEOD-38604 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress