Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Linda Buck
PROVIDER: E-GEOD-75413 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Hanchate Naresh K NK Kondoh Kunio K Lu Zhonghua Z Kuang Donghui D Ye Xiaolan X Qiu Xiaojie X Pachter Lior L Trapnell Cole C Buck Linda B LB
Science (New York, N.Y.) 20151105 6265
The sense of smell allows chemicals to be perceived as diverse scents. We used single-neuron RNA sequencing to explore the developmental mechanisms that shape this ability as nasal olfactory neurons mature in mice. Most mature neurons expressed only one of the ~1000 odorant receptor genes (Olfrs) available, and at a high level. However, many immature neurons expressed low levels of multiple Olfrs. Coexpressed Olfrs localized to overlapping zones of the nasal epithelium, suggesting regional biase ...[more]