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Dnmt3a protects active chromosome domains against cancer-associated hypomethylation

ABSTRACT: The results of the study uncover conserved features of cancer methylomes and provide a mechanistic explanation for the tumor-promoting effects of Dnmt3a mutations. Whole genome methylation analysis of Mus musculus. Five samples were analyzed, one control sample containing normal healthy lung tissue, two samples containing big (WTB) or small (WTS) Dnmt3a WT tumors, two samples containing big (KOB) or small (KOS) Dnmt3a knock-out tumors

ORGANISM(S): Mus musculus

SUBMITTER: Guenter Raddatz

PROVIDER: E-GEOD-38651 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Dnmt3a protects active chromosome domains against cancer-associated hypomethylation.

Raddatz Günter G Gao Qing Q Bender Sebastian S Jaenisch Rudolf R Lyko Frank F

PLoS genetics 20121220 12

Changes in genomic DNA methylation patterns are generally assumed to play an important role in the etiology of human cancers. The Dnmt3a enzyme is required for the establishment of normal methylation patterns, and mutations in Dnmt3a have been described in leukemias. Deletion of Dnmt3a in a K-ras-dependent mouse lung cancer model has been shown to promote tumor progression, which suggested that the enzyme might suppress tumor development by stabilizing DNA methylation patterns. We have used whol ...[more]

PMID: 23284304

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