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GEP of the murine cell line BAL17 (BALB/c)

ABSTRACT: GEP of the murine cell line BAL17 (BALB/c) BAL17- / BAL17VII-induced primary CNS lymphoma analysis. 5x10^5 cells were implanted into the brain of BALB/c wt mice and analyzed 21 and 28 days post implantation. The cell lines were also analyzed.

ORGANISM(S): Mus musculus

SUBMITTER: Manuel Montesinos-Rongen

PROVIDER: E-GEOD-38675 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Mechanisms of intracerebral lymphoma growth delineated in a syngeneic mouse model of central nervous system lymphoma.

Montesinos-Rongen Manuel M Sánchez-Ruiz Mónica M Brunn Anna A Hong Ke K Bens Susanne S Perales Sandra Rodriguez SR Cigudosa Juan C JC Siebert Reiner R Deckert Martina M

Journal of neuropathology and experimental neurology 20130401 4

Primary lymphoma of the central nervous system (PCNSL) is defined as lymphoma of the diffuse large B-cell type confined to the CNS. To understand the effects of the CNS microenvironment on the malignant B cells and their interactions with the cells of the target organ, we analyzed a syngeneic mouse model. Transplantation of BAL17 cells into the frontal white matter of syngeneic BALB/c mice induced lymphomas with major clinical and neuropathologic features that parallel those of human PCNSL, incl ...[more]

PMID: 23481709

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