Effects of rraA deletion on transcription
Ontology highlight
ABSTRACT:
ORGANISM(S): Escherichia coli
SUBMITTER: Kangseok Lee
PROVIDER: E-GEOD-3869 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
RraA. a protein inhibitor of RNase E activity that globally modulates RNA abundance in E. coli.
Lee Kangseok K Zhan Xiaoming X Gao Junjun J Qiu Ji J Feng Yanan Y Meganathan R R Cohen Stanley N SN Georgiou George G
Cell 20030901 5
Ribonuclease E (RNase E) has a key role in mRNA degradation and the processing of catalytic and structural RNAs in E. coli. We report the discovery of an evolutionarily conserved 17.4 kDa protein, here named RraA (regulator of ribonuclease activity A) that binds to RNase E and inhibits RNase E endonucleolytic cleavages without altering cleavage site specificity or interacting detectably with substrate RNAs. Overexpression of RraA circumvents the effects of an autoregulatory mechanism that normal ...[more]
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