A common set of DNA regulatory elements shapes Drosophila appendages

ABSTRACT: We mapped open chromatin by FAIRE-seq and measured gene expression by RNA-seq in 3 types of Drosophila samples: staged whole embryos, imaginal discs, pharate appendages. We first demonstrate that regions of open chromatin precisely define regions of enhancer activity in developing embryos. In contrast to the dynamic changes in open chromatin observed between different stages of embryogenesis, we found that the open chromatin profiles in wing, leg, and haltere imaginal discs are nearly identical. This was also true again later in development, where the adult appendages also share nearly identical open chromatin profiles. Therefore, at a given developmental time point, different appendages are specified using a shared set of DNA regulatory elements. However, from one time point to the next,

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Daniel McKay 

PROVIDER: E-GEOD-38727 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress