Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Thomas Burkard
PROVIDER: E-GEOD-38764 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Berger Christian C Harzer Heike H Burkard Thomas R TR Steinmann Jonas J van der Horst Suzanne S Laurenson Anne-Sophie AS Novatchkova Maria M Reichert Heinrich H Knoblich Juergen A JA
Cell reports 20120809 2
Drosophila neuroblasts (NBs) have emerged as a model for stem cell biology that is ideal for genetic analysis but is limited by the lack of cell-type-specific gene expression data. Here, we describe a method for isolating large numbers of pure NBs and differentiating neurons that retain both cell-cycle and lineage characteristics. We determine transcriptional profiles by mRNA sequencing and identify 28 predicted NB-specific transcription factors that can be arranged in a network containing hubs ...[more]