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Human regulatory T cells induce lymphocyte senescence

ABSTRACT: Analysis of gene alternations during the process of senescence induced by human regulatory T cells at various time points. Total RNA obtained from isolated regulatory T (Treg) cell-treated responder CD8+ T cells compared to the untreated T cells

ORGANISM(S): Homo sapiens

SUBMITTER: Guangyong Peng

PROVIDER: E-GEOD-38765 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Human regulatory T cells induce T-lymphocyte senescence.

Ye Jian J Huang Xingxu X Hsueh Eddy C EC Zhang Qunyuan Q Ma Chunling C Zhang Yanping Y Varvares Mark A MA Hoft Daniel F DF Peng Guangyong G

Blood 20120621 10

Regulatory T (Treg) cells have broad suppressive activity on host immunity, but the fate and function of suppressed responder T cells remains largely unknown. In the present study, we report that human Treg cells can induce senescence in responder naive and effector T cells in vitro and in vivo. Senescent responder T cells induced by human Treg cells changed their phenotypes and cytokine profiles and had potent suppressive function. Furthermore, Treg-mediated molecular control of senescence in r ...[more]

PMID: 22723548

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