Ontology highlight
ABSTRACT:
SUBMITTER: Ye J
PROVIDER: S-EPMC3437594 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Blood 20120621 10
Regulatory T (Treg) cells have broad suppressive activity on host immunity, but the fate and function of suppressed responder T cells remains largely unknown. In the present study, we report that human Treg cells can induce senescence in responder naive and effector T cells in vitro and in vivo. Senescent responder T cells induced by human Treg cells changed their phenotypes and cytokine profiles and had potent suppressive function. Furthermore, Treg-mediated molecular control of senescence in r ...[more]