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Intratumoral diversity in Follicular lymphoma

ABSTRACT: Follicular lymphoma (FL) shows heterogenous expression of the cell surface B-cell marker, CD20. In order to investigate whether this heterogeneity also marks underlying transcriptional heterogeneity, we sorted tumor B-cells from 8 FL specimens based upon their intermediate or high expression of CD20 and transcriptionally profiled them. CD20 intermediate and CD20 high tumor B-cells were sorted by FACS, RNA extracted, and profiled using Affymetrix U133 plus 2.0 microarrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Green

PROVIDER: E-GEOD-38816 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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