Scleroderma Morphea Normal Fibroblasts
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Michael Whitfield
PROVIDER: E-GEOD-3886 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Systemic and cell type-specific gene expression patterns in scleroderma skin.
Whitfield Michael L ML Finlay Deborah R DR Murray John Isaac JI Troyanskaya Olga G OG Chi Jen-Tsan JT Pergamenschikov Alexander A McCalmont Timothy H TH Brown Patrick O PO Botstein David D Connolly M Kari MK
Proceedings of the National Academy of Sciences of the United States of America 20031006 21
We used DNA microarrays representing >12,000 human genes to characterize gene expression patterns in skin biopsies from individuals with a diagnosis of systemic sclerosis with diffuse scleroderma. We found consistent differences in the patterns of gene expression between skin biopsies from individuals with scleroderma and those from normal, unaffected individuals. The biopsies from affected individuals showed nearly indistinguishable patterns of gene expression in clinically affected and clinica ...[more]
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