Unknown,Transcriptomics,Genomics,Proteomics

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Analysis of Pro-Inflammatory Gene Activation and RNA Processing by RNAseq of Nascent Transcripts [supplement]


ABSTRACT: Note: These datasets are in supplement to, but separate from, Geo GSE32916. We examined pro-inflammatory gene activation in activated wildtype and IFNAR-/- murine macrophages by performing RNA-Seq with poly(A) enriched transcripts. This experimental strategy allowed a global, high-resolution analysis of the transcriptional regulation of diverse classes of co-expressed genes and allowed us to identify co-expressed gene classes that may depend on IFN-signaling for its expression. The results provide quantitative insights into the relationship between transcription and distinct promoter and chromatin properties. RNA-seq of poly(A) enriched RNA from five stimulation time-points in wildtype and IFNAR-/- macrophages

ORGANISM(S): Mus musculus

SUBMITTER: Stephen Smale 

PROVIDER: E-GEOD-38892 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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