Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human microvascular endothelial cells undergoing proliferation or tubulogenesis


ABSTRACT: Human microvascular endothelial cells were stimulated to either proliferate or undergo tubulogenesis over an 8 hour time period.

ORGANISM(S): Homo sapiens

SUBMITTER: suneeta mandava 

PROVIDER: E-GEOD-3891 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Subtractive transcriptomics: establishing polarity drives in vitro human endothelial morphogenesis.

Glesne David A DA   Zhang Wen W   Mandava Suneeta S   Ursos Lyann L   Buell Margaret E ME   Makowski Lee L   Rodi Diane J DJ  

Cancer research 20060401 8


Although investigations of mature normal and tumor-derived capillaries have resulted in characterization of these structures at the phenotypic level, less is known regarding the initial molecular cues for cellular assembly of endothelial cells into human capillaries. Here, we employ a novel combination of microenvironmental manipulation and microarray data filtration over narrowly delineated temporal data series to identify the morphogenesis component apart from the proliferation component, as p  ...[more]

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