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Transcription profiling of human ALL - 35 patients at diagnosis and relapse

ABSTRACT: 35 paired samples from initial diagnosis and first marrow relapse. Genes and pathways differentiating diagnosis and relapse were identified. Potential therapeutic targets were also identified. Experiment Overall Design: 35 patients with samples from initial diagnosis and first marrow relapse.

ORGANISM(S): Homo sapiens

SUBMITTER: Deepa Bhojwani

PROVIDER: E-GEOD-3910 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Biologic pathways associated with relapse in childhood acute lymphoblastic leukemia: a Children's Oncology Group study.

Bhojwani Deepa D Kang Huining H Moskowitz Naomi P NP Min Dong-Joon DJ Lee Hokyung H Potter Jeffrey W JW Davidson George G Willman Cheryl L CL Borowitz Michael J MJ Belitskaya-Levy Ilana I Hunger Stephen P SP Raetz Elizabeth A EA Carroll William L WL

Blood 20060701 2

Outcome for children with childhood acute lymphoblastic leukemia (ALL) who relapse is poor. To gain insight into the mechanisms of relapse, we analyzed gene-expression profiles in 35 matched diagnosis/relapse pairs as well as 60 uniformly treated children at relapse using the Affymetrix platform. Matched-pair analyses revealed significant differences in the expression of genes involved in cell-cycle regulation, DNA repair, and apoptosis between diagnostic and early-relapse samples. Many of these ...[more]

PMID: 16822902

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