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IMR32 was transduced with control or shMYCN virus (duplo). For each experiment 3 time points were analyzed and 2 no virus controls.

ABSTRACT: IMR32 was transduced with control or shMYCN virus (duplo). For each experiment 3 time points were analyzed and 2 no virus controls. IMR32 was transduced with control or shMYCN virus (duplo). For each experiment 3 time points were analyzed and 2 no virus controls.

ORGANISM(S): Homo sapiens

SUBMITTER: Rogier Versteeg

PROVIDER: E-GEOD-39218 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification.

Valentijn Linda J LJ Koster Jan J Haneveld Franciska F Aissa Rachida Ait RA van Sluis Peter P Broekmans Marloes E C ME Molenaar Jan J JJ van Nes Johan J Versteeg Rogier R

Proceedings of the National Academy of Sciences of the United States of America 20121022 47

Neuroblastoma is a pediatric tumor of the sympathetic nervous system. MYCN (V-myc myelocytomatosis viral-related oncogene, neuroblastoma derived [avian]) is amplified in 20% of neuroblastomas, and these tumors carry a poor prognosis. However, tumors without MYCN amplification also may have a poor outcome. Here, we identified downstream targets of MYCN by shRNA-mediated silencing MYCN in neuroblastoma cells. From these targets, 157 genes showed an expression profile correlating with MYCN mRNA lev ...[more]

PMID: 23091029

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