Chip-chip investigation of the effcts of phthalate plastisizers on fetal rat testes
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ABSTRACT: ChIP microarrays were used to investigate whether dibutylphthalate (DBP)-mediated repression of SF1-regulated genes was associated with changes in transcription factor binding to genes involved in DBP-induced testicular maldevelopment. The repressive effect of DBP on SF1 regulated gene expression in fetal testes correlates with inhibition of SF1 binding to steroidogenic gene promoters. Comparison of control- and DBP- in utero 500mg/Kg treated fetal rat testes
ORGANISM(S): Rattus norvegicus
SUBMITTER: Simon Plummer
PROVIDER: E-GEOD-39225 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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