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Transcription profiling of whole fetal rat testes at gestational days 15, 17 and 19 treated in utero with dibutylphthalate (DBP)

ABSTRACT: An experiment was performed to assess the effects on rats of in utero dibutylphthalate (DBP)-treatment on the transcriptome of whole fetal testes at gestational days 15, 17 and 19.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Simon Plummer

PROVIDER: E-TABM-200 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Time-dependent and compartment-specific effects of in utero exposure to Di(n-butyl) phthalate on gene/protein expression in the fetal rat testis as revealed by transcription profiling and laser capture microdissection.

Plummer Simon S Sharpe Richard M RM Hallmark Nina N Mahood Isobel Kim IK Elcombe Cliff C

Toxicological sciences : an official journal of the Society of Toxicology 20070322 2

We undertook transcription profiling of fetal testis RNA on gestational days e15.5, 17.5, and 19.5 in offspring from dams treated daily from e12.5 with 500 mg/kg di(n-butyl) phthalate (DBP). At e17.5-19.5, reduced expression of genes involved in cholesterol uptake/metabolism and steroidogenesis was identified in DBP-exposed animals, including scavenger receptor B1 (SCARB1), HMGCoA synthase, steroidogenic acute regulatory protein, Cyp11a, and Cyp17. Genes encoding inhibin-alpha, phosphatidylethan ...[more]

PMID: 17379624

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