Effects of methylseleninic acid on prostate cancer cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Hongjuan Zhao
PROVIDER: E-GEOD-3924 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Diverse effects of methylseleninic acid on the transcriptional program of human prostate cancer cells.
Zhao Hongjuan H Whitfield Michael L ML Xu Tong T Botstein David D Brooks James D JD
Molecular biology of the cell 20031114 2
Methylseleninic acid (MSA) has been shown to have potent anticancer activity and is an excellent compound for studying the anticancer effects of selenium in vitro. To gain insights into the effects of MSA in prostate cancer, we characterized the global transcriptional response of LNCaP, an androgen-sensitive human prostate cancer cell line, to MSA by using high-density cDNA microarrays. We identified 951 genes whose expression shows striking dose- and time-dependent changes in response to 3-30 m ...[more]
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