Human CRC cell populations
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Alexandre CALON
PROVIDER: E-GEOD-39397 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation.
Calon Alexandre A Espinet Elisa E Palomo-Ponce Sergio S Tauriello Daniele V F DV Iglesias Mar M Céspedes María Virtudes MV Sevillano Marta M Nadal Cristina C Jung Peter P Zhang Xiang H-F XH Byrom Daniel D Riera Antoni A Rossell David D Mangues Ramón R Massagué Joan J Sancho Elena E Batlle Eduard E
Cancer cell 20121101 5
A large proportion of colorectal cancers (CRCs) display mutational inactivation of the TGF-β pathway, yet, paradoxically, they are characterized by elevated TGF-β production. Here, we unveil a prometastatic program induced by TGF-β in the microenvironment that associates with a high risk of CRC relapse upon treatment. The activity of TGF-β on stromal cells increases the efficiency of organ colonization by CRC cells, whereas mice treated with a pharmacological inhibitor of TGFBR1 are resilient to ...[more]
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