Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: J Calabrese
PROVIDER: E-GEOD-39406 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Calabrese J Mauro JM Sun Wei W Song Lingyun L Mugford Joshua W JW Williams Lucy L Yee Della D Starmer Joshua J Mieczkowski Piotr P Crawford Gregory E GE Magnuson Terry T
Cell 20121101 5
The inactive X chromosome's (Xi) physical territory is microscopically devoid of transcriptional hallmarks and enriched in silencing-associated modifications. How these microscopic signatures relate to specific Xi sequences is unknown. Therefore, we profiled Xi gene expression and chromatin states at high resolution via allele-specific sequencing in mouse trophoblast stem cells. Most notably, X-inactivated transcription start sites harbored distinct epigenetic signatures relative to surrounding ...[more]