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Expression profile of the endocrine therapy sensitive breast cancer cells MCF7 depleted of PBX1

ABSTRACT: Effect of PBX1 silencing on global gene expression of MCF7 cells stimulated with EGF. The hypothesis tested was that PBX1 is essential for EGF signaling in ERa positive breast cancer cells. Total RNA was obtained from MCF7 cells treated with siRNA directed at PBX1 or an siControl for 72h. Cells were then stimulated with estradiol (EGF) for 3h prior to RNA extraction.

ORGANISM(S): Homo sapiens

SUBMITTER: luca magnani 

PROVIDER: E-GEOD-39417 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer.

Magnani Luca L   Stoeck Alexander A   Zhang Xiaoyang X   Lánczky András A   Mirabella Anne C AC   Wang Tian-Li TL   Gyorffy Balázs B   Lupien Mathieu M  

Proceedings of the National Academy of Sciences of the United States of America 20130401 16

The estrogen receptor (ER)α drives growth in two-thirds of all breast cancers. Several targeted therapies, collectively termed endocrine therapy, impinge on estrogen-induced ERα activation to block tumor growth. However, half of ERα-positive breast cancers are tolerant or acquire resistance to endocrine therapy. We demonstrate that genome-wide reprogramming of the chromatin landscape, defined by epigenomic maps for regulatory elements or transcriptional activation and chromatin openness, underli  ...[more]

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