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MicroRNA-138: A Pro-survival OncomiR for Glioma Stem Cells is Associated with Tumor Recurrence [mRNA]

ABSTRACT: We report the identification of microRNA-138 (miR-138), as a molecular signature of GSCs and demonstrate a vital role for miR-138 to promote growth and survival of bona fide tumor-initiating cells with self-renewal potential. Keywords: Expression profiling by array Total RNA from GSCs 5 days after transduction with lentivirus expressing anti-miR-138 or scrambled sequence was subjected to microarray analysis

ORGANISM(S): Homo sapiens

SUBMITTER: Prabha Sampath

PROVIDER: E-GEOD-39487 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Targeting glioma stem cells by functional inhibition of a prosurvival oncomiR-138 in malignant gliomas.

Chan Xin Hui Derryn XH Nama Srikanth S Gopal Felicia F Rizk Pamela P Ramasamy Srinivas S Sundaram Gopinath G Ow Ghim Siong GS Ivshina Anna Vladimirovna AV Tanavde Vivek V Haybaeck Johannes J Kuznetsov Vladimir V Sampath Prabha P

Cell reports 20120824 3

Malignant gliomas are the most aggressive forms of brain tumors, associated with high rates of morbidity and mortality. Recurrence and tumorigenesis are attributed to a subpopulation of tumor-initiating glioma stem cells (GSCs) that are intrinsically resistant to therapy. Initiation and progression of gliomas have been linked to alterations in microRNA expression. Here, we report the identification of microRNA-138 (miR-138) as a molecular signature of GSCs and demonstrate a vital role for miR-13 ...[more]

PMID: 22921398

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