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Tumoral transcriptome profiling of tPTEN-/- mice.

ABSTRACT: tPTEN-/- mice display a deletion of the PTEN tumor suppressor gene specifically in T cells (cross PTEN flox/flox x lck-Cre). They develop T cell lymphoma with a primary thymic tumor and invasion of most organ at late stage of the disease. Gene profiling was performed on whole tumors (ST3 stage 3 invasive lymphoma) and normal thymocytes (wt) using Affymetrix-MoGene-1_0-st-v1 chips.

ORGANISM(S): Mus musculus

SUBMITTER: Kevin Lebrigand 

PROVIDER: E-GEOD-39591 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Pharmacological inhibition of carbonic anhydrase XII interferes with cell proliferation and induces cell apoptosis in T-cell lymphomas.

Lounnas Nadia N   Rosilio Célia C   Nebout Marielle M   Mary Didier D   Griessinger Emmanuel E   Neffati Zouhour Z   Chiche Johanna J   Spits Hergen H   Hagenbeek Thijs J TJ   Asnafi Vahid V   Poulsen Sally-Ann SA   Supuran Claudiu T CT   Peyron Jean-François JF   Imbert Véronique V  

Cancer letters 20130121 1

The membrane-bound carbonic anhydrase isoforms CAIX and CAXII, underpin a pH-regulating system that enables hypoxic tumor cell survival. Here, we observed for the first time an upregulation of CAXII in T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LL) cells. First we showed that CAXII is overexpressed in thymocytes from tPTEN-/- mice suffering of T lymphoma and that its pharmacological inhibition decreased cell proliferation and induced apoptosis. The same results were observed with the Su  ...[more]

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