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Transcription profiling of hippocampus and amygdala from na´ve, conditioned and fear stimuls exposted mice

ABSTRACT: Hippocampus and amygdala expression was examined in naive, conditioned stimulus exposed, and fear conditioned mice 30 minutes after behavioral manipulation

ORGANISM(S): Mus musculus

SUBMITTER: Ted Abel

PROVIDER: E-GEOD-3963 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Differential transcriptional response to nonassociative and associative components of classical fear conditioning in the amygdala and hippocampus.

Keeley Michael B MB Wood Marcelo A MA Isiegas Carolina C Stein Joel J Hellman Kevin K Hannenhalli Sridhar S Abel Ted T

Learning & memory (Cold Spring Harbor, N.Y.) 20060317 2

Classical fear conditioning requires the recognition of conditioned stimuli (CS) and the association of the CS with an aversive stimulus. We used Affymetrix oligonucleotide microarrays to characterize changes in gene expression compared to naive mice in both the amygdala and the hippocampus 30 min after classical fear conditioning and 30 min after exposure to the CS in the absence of an aversive stimulus. We found that in the hippocampus, levels of gene regulation induced by classical fear condi ...[more]

PMID: 16547164

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