Unknown,Transcriptomics,Genomics,Proteomics

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Invasive lobular and ductal carcinomas of the breast


ABSTRACT: This set of experiments includes 38 IDCs, 21 ILCs, 2 lymphnode metastases, and 3 normal breast samples. It is designed to compare gene expression profiles of IDCs and ILCs. Total RNAs from all samples were isolated using TRIzol, amplified using optimized T7 linear amplification protocol, and labeled with Cy5. Stratagen Universal Human Reference RNA was amplified the same way and labeled with Cy3. Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. Computed

ORGANISM(S): Homo sapiens

SUBMITTER: Hongjuan Zhao 

PROVIDER: E-GEOD-3971 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Different gene expression patterns in invasive lobular and ductal carcinomas of the breast.

Zhao Hongjuan H   Langerød Anita A   Ji Youngran Y   Nowels Kent W KW   Nesland Jahn M JM   Tibshirani Rob R   Bukholm Ida K IK   Kåresen Rolf R   Botstein David D   Børresen-Dale Anne-Lise AL   Jeffrey Stefanie S SS  

Molecular biology of the cell 20040319 6


Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) are the two major histological types of breast cancer worldwide. Whereas IDC incidence has remained stable, ILC is the most rapidly increasing breast cancer phenotype in the United States and Western Europe. It is not clear whether IDC and ILC represent molecularly distinct entities and what genes might be involved in the development of these two phenotypes. We conducted comprehensive gene expression profiling studies to addres  ...[more]

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