Unknown,Transcriptomics,Genomics,Proteomics

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Effect of fludioxonil treatment on candida albicans SC5314


ABSTRACT: Comparison of Candida albicans SC5314 treated with fludioxonil for 30 min and untreated controls under hyphae-inducing conditions 3 biologically independent replicates of a reference sample (U30) and fludioxonil treatment (F30) each

ORGANISM(S): Candida albicans SC5314

SUBMITTER: Anna Buschart 

PROVIDER: E-GEOD-39715 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The fungicide fludioxonil antagonizes fluconazole activity in the human fungal pathogen Candida albicans.

Buschart Anna A   Burakowska Anna A   Bilitewski Ursula U  

Journal of medical microbiology 20120823 Pt 12


The fungicide fludioxonil is widely used in agriculture. Residua of this fungicide are occasionally detected in fruits and can therefore be ingested by humans. The human fungal pathogen Candida albicans expresses the target of fludioxonil, Nik1p, a type III histidine kinase involved in stress response. Inhibition of yeast and hyphae growth was hardly observable after treatment of C. albicans SC5314 with fludioxonil. As a side effect, however, we observed a concentration-dependent induction of th  ...[more]

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