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Ovarian cancer cell lines PEA1 in low glucose condition shows metabolism-driven inflammation

ABSTRACT: Transcription profiling by array of PEA1 cell lines in low glucose growth condition compared to normal growth condition

ORGANISM(S): Homo sapiens

SUBMITTER: Vittorio Simeon

PROVIDER: E-MTAB-3799 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Oxidative metabolism drives inflammation-induced platinum resistance in human ovarian cancer.

Matassa D S DS Amoroso M R MR Lu H H Avolio R R Arzeni D D Procaccini C C Faicchia D D Maddalena F F Simeon V V Agliarulo I I Zanini E E Mazzoccoli C C Recchi C C Stronach E E Marone G G Gabra H H Matarese G G Landriscina M M Esposito F F

Cell death and differentiation 20160520 9

Tumour cells have long been considered defective in mitochondrial respiration and mostly dependent on glycolytic metabolism. However, this assumption is currently challenged by several lines of evidence in a growing number of tumours. Ovarian cancer (OC) is one of the most lethal cancers worldwide, but it continues to be a poorly understood disease and its metabolic features are far to be elucidated. In this context, we investigated the role of tumour necrosis factor receptor-associated protein ...[more]

PMID: 27206315

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