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HSC-3 cells (control) vs. HSC-3-5 cells [subcutaneous tumor]

ABSTRACT: HSC-3-5 cells, which drived from human HSC-3 cells via transwell invasion assay was high invasive.Tumor cells were injected into the flank of SCID mice. After 6 weeks, transcriptional profiling of human HSC-3 tumor comparing with high invasive HSC-3-5 tumor. Goal was to determine the effects of invasion on global HSC-3-5 gene expression during tumor metastasis. HSC-3 and HSC-3-5 oral cancer cells were respectively injected into the flank and tongue of SCID mice. After 1 and 6 weeks, total RNA was respectively extracted from the tumor tissue on tongue and flank of SCID mice for gene expression profiling during metastasis. Briefly, two-condition experiment,HSC-3 vs. HSC-3-5 cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Chuan-Fa Chang 

PROVIDER: E-GEOD-39726 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Anterior gradient 2: a novel sensitive tumor marker for metastatic oral cancer.

Chen Yi-Ting YT   Ho Chung-Liang CL   Chen Po-Ku PK   Chen Yuh-Ling YL   Chang Chuan-Fa CF  

Cancer letters 20130705 2

The prevention of oral squamous cell carcinoma metastasis to improve overall patient survival has provided the rationale for biomarker development. We used the Transwell invasion assay to isolate a highly metastatic subpopulation, HSC-3-5 cells, with almost the same genetic background as HSC-3 cells but a higher metastatic capacity accompanied by cytoskeletal rearrangements and mesenchymal transformation. HSC-3-5 cells also showed tumorigenic and metastatic characteristics in vivo. In addition,  ...[more]

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