Unknown,Transcriptomics,Genomics,Proteomics

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Sensory ray genes

ABSTRACT: These experiments were undertaken with the goal of identifying genes whose expression is enriched in or restricted to the sensory rays of the C. elegans male tail. We constructed two mutant strains in which ray development is either compromised (EM672) or enhanced (EM673), and harvested mRNA from adult males. Labeled cDNAs were compared on seven arrays (representing three different sets of mRNA preps). In all experiments, Channel 1 (green) represents the EM672 expression profile and Channel 2 (Red) corresponds to EM673. Ray-enriched genes would therefore generally be expected to have higher intensities in Channel 2 than in Channel 1. Experimental details and results from these studies are available in D.S. Portman and S.W. Emmons (2004) Identification of C. elegans sensory ray genes using whole-genome expression profiling. Groups of assays that are related as part of a time series. Computed

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Douglas Portman

PROVIDER: E-GEOD-3979 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Identification of C. elegans sensory ray genes using whole-genome expression profiling.

Portman Douglas S DS Emmons Scott W SW

Developmental biology 20040601 2

The three cells that comprise each C. elegans sensory ray (two sensory neurons and a structural cell) descend from a single neuroblast precursor cell. The atonal ortholog lin-32 and the E/daughterless ortholog hlh-2 act to confer neural competence during ray development, but additional regulatory factors that control specific aspects of cell fate are largely unknown. Here, we use full-genome DNA microarrays to compare gene expression profiles in adult males of two mutant strains to identify new ...[more]

PMID: 15183729

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Dataset Information

Sensory ray genes

Publications

Identification of C. elegans sensory ray genes using whole-genome expression profiling.

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